Towards treating progressive multiple sclerosis
نویسندگان
چکیده
منابع مشابه
Primary-progressive multiple sclerosis.
About 10-15% of patients with multiple sclerosis (MS) present with gradually increasing neurological disability, a disorder known as primary-progressive multiple sclerosis (PPMS). Compared with relapse-onset multiple sclerosis, people with PPMS are older at onset and a higher proportion are men. Inflammatory white-matter lesions are less evident but diffuse axonal loss and microglial activation...
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10.2217/14750708.4.3.339 © 2 Approximately one in two multiple sclerosis patients will develop a major depression over the course of their lifetime. This is associated with a decreased quality of life and a high risk of completed suicide. A literature review suggests pharmacotherapy with a selective serotonin-reuptake inhibitor or tricyclic antidepressant is effective, the former likely better ...
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A number of studies have been conducted with the onset of secondary progressive multiple sclerosis as an inclusion criterion or an outcome of interest. However, a standardized objective definition of secondary progressive multiple sclerosis has been lacking. The aim of this work was to evaluate the accuracy and feasibility of an objective definition for secondary progressive multiple sclerosis,...
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Multiple sclerosis (MS) is a common inflammatory disease of the nervous system that generally starts in young adulthood and over time frequently leads to progressive functional deficits. A characteristic of this still puzzling disease is that its clinical manifestation changes as it progresses. Although during the early phases of the disorder, most patients mainly experience relapses, on averag...
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Until recently, multiple sclerosis has been viewed as an entirely inflammatory disease without acknowledgment of the significant neurodegenerative component responsible for disease progression and disability. This perspective is being challenged by observations of a dissociation between inflammation and neurodegeneration where the neurodegenerative component may play a more significant role in ...
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ژورنال
عنوان ژورنال: Nature Reviews Neurology
سال: 2020
ISSN: 1759-4758,1759-4766
DOI: 10.1038/s41582-020-00421-4